qirssi is a trayicon and message notifier for irssi.
You can open and close easily a terminal window containing a screen session running irssi by using the qirssi trayicon. You can get new message alerts by icon and/or balloon alerts. The alerts are also configurable by regular expressions. You can, for example, get alerts only for private messages from some nicks. It is not required to run DBus nor notification-daemon. All the required communication is done using plain Unix Domain Sockets.