Projects

tinatool

AbstractCombining experimental and theoretical approaches to enlighten the functioning of molecular processes in the cell is a main goal in systems biology. Theoretical modelling of biological systems in particular will become more and more important to reduce wet lab experiments for target finding. ... [More] Based on qualitative Petri net models, a minimal set of basic pathways at steady state, the transition invariants (T-invariants) or elementary modes, respectively, can be computed. In the case of complex and large networks, the number of T-invariants increases exponentially. Thus, new concepts for further network decomposition into biologically meaningful pathways have been developed, such as MCT-sets, T-clusters, and Mauritius maps. We have developed a software tool which compiles all these concepts providing a user-friendly interface and interfaces to Petri nets and systems biology standards. TInA ToolTInA tool is a comprehensive toolset for T-invariant related calculations in biological networks at steady state. TInA Tool Beta ReleaseCheck out our beta prereleases in the Downloads section. Please note that the software is far from finished and we are continually working to improve it. If you have found bugs or would like to voice suggestions/comments, please do so by dropping us a mail, or using the Issue tracker. [Less]