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RetroShare is a cross-platform private P2P sharing program. It lets you share securely your friends, using a web-of-trust to authenticate peers and OpenSSL to encrypt all communication. RetroShare provides filesharing, chat, messages and channels.
Museek-Plus is a program-suite for the C++ museek daemon, a Soulseek/Soulfind P2P client. It includes the QT GUI, Museeq, and the Python/Curses TUI, Mucous. It supports chat, transferring files, searching, user-management shares browsing and more.
tcpfile is a filetransfer / filesharing / instant messaging java(1.6) program offering zipped and fully encrypted (RSA,AES) communication.
Gloster is a secure and decentralized p2p program for small communities working under Linux and Windows
DC:PRO is a client for the Direct-Connect-File-Sharing. Among other things it features segmented downloading, user-friendly interface, multi-hub connections, chat with colors and images. The developer disappeared. The latest source has not been released!
An Instant Messaging App which utilizes the newly released facebook.com developer API (developers.facebook.com) to merge Instant Messaging with the facebook.com community experience.