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Bugzilla is a web-based bug tracking tool. It works with an existing web server, e.g. Apache, and with an existing SQL database, e.g. MySQL or PostgreSQL.
Mantis is an easily deployable, web based bugtracker to aid product bug tracking. It requires PHP, MySQL and a web server. It is simpler than Bugzilla and easily editable. Check out the online Demo.
epesiBIM = Business Information Manager. A little more than just CRM: multiuser addressbook, calendar, to do list, notes and file attachments. Can be extended and customized using included epesi framework. Allows rapid development of new modules.
Project Manager and Bug Tracker for Agile Software Development. Flexible Task Workflows and Views. Supports Velocity and Iterations planning. Web-based, Easy to install and user friendly. Supports unicode.
Try it online at http://openprojectmanager.com
Tosca is an Open Source bugtracker. It is designed to be user friendly, professional and multi-projects. It is made with Ruby on Rails.